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Yankees at Blue Jays Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for July 22

It’s Tuesday, July 22 and the Yankees (55-45) are in Toronto to take on the Blue Jays (59-41). Cam Schlittler is slated to take the mound for New York against Max Scherzer for Toronto.

The Blue Jays won the opening game 4-1 behind a four-run fifth inning to extend its home winning streak to 11 games and five consecutive over the Yankees. New York is now 2-4 over the last six games, while Toronto has won four straight out the break.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Yankees at Blue Jays

Date: Tuesday, July 22, 2025
Time: 7:07PM EST
Site: Rogers Centre
City: Toronto, ON
Network/Streaming: YES, Sportsnet

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Yankees at the Blue Jays

The latest odds as of Tuesday:

Moneyline: Yankees (+108), Blue Jays (-128)
Spread: Blue Jays -1.5
Total: 9.0 runs

Probable starting pitchers for Yankees at Blue Jays

Pitching matchup for July 22, 2025: Cam Schlittler vs. Max Scherzer
- Yankees: Cam Schlittler, (1-0, 5.06 ERA)
  Last outing: 5.1 Innings Pitched, 3 Earned Runs Allowed, 4 Hits Allowed, 2 Walks, and 7 Strikeouts
- Blue Jays: Max Scherzer, (1-0, 4.70 ERA)
  Last outing: 6.0 Innings Pitched, 3 Earned Runs Allowed, 5 Hits Allowed, 1 Walk, and 8 Strikeouts

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Expert picks & predictions for tonight’s game between the Yankees and the Blue Jays

Rotoworld Best Bet

Vaughn Dalzell (@VmoneySports) likes the value on the Yankees to win the AL East:

“This series will be a defining one in the AL East race that has seen the Toronto Blue Jays take ahold of. Toronto is up in the series season and swept New York earlier in the season, so it’s an ideal time for the Yankees to strike back.

The odds are down to plus-money on the Yankees to win the division, which could be back to -150 with a series win over the Blue Jays.”

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Yankees and the Blue Jays:

Moneyline: NBC Sports Bet is recommending a play on the Toronto Blue Jays on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New York Yankees at +1.5.
Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Yankees at Blue Jays

New York is 1-0 in Schlittler’s starts
Toronto has won three straight with Scherzer
The Blue Jays have won 7 of their last 8 matchups against AL East opponents
The Over is 4-1 in the Yankees’ last 5 divisional matchups
The Blue Jays are up 3.62 units on the Run Line in their last 5 at home

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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