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Twins at Dodgers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for July 22

Its Tuesday, July 22 and the Twins (48-52) are in Los Angeles to take on the Dodgers (59-42) in Game 2 of their series.

Simeon Woods Richardson is slated to take the mound for Minnesota against Yoshinobu Yamamoto for Los Angeles.

Shohei Ohtani allowed a Byron Buxton home run in the top of the first inning last night but got the run plus one back in the bottom of the first with his 35th home run of the season as the Dodgers rolled to a 5-2 win in the series opener against the Twins. Will Smith went yard in the fourth and sixth innings to seal the win for LA.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Twins at Dodgers

Date: Tuesday, July 22, 2025
Time: 10:10PM EST
Site: Dodger Stadium
City: Los Angeles, CA
Network/Streaming: MNNT, SNLA, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Twins at the Dodgers

The latest odds as of Tuesday:

Moneyline: Twins (+182), Dodgers (-222)
Spread: Dodgers -1.5
Total: 8.0 runs

Probable starting pitchers for Twins at Dodgers

Pitching matchup for July 22, 2025: Simeon Woods Richardson vs. Yoshinobu Yamamoto
- Twins: Simeon Woods Richardson (5-4, 3.95 ERA)
  Last outing: July 13 vs. Pittsburgh - 4.2IP, 1ER, 6H, 1BB, 3Ks
- Dodgers: Yoshinobu Yamamoto (8-7, 2.59 ERA)
  Last outing: July 13 at San Francisco - 7IP, 0ER, 3H, 2BB, 7Ks

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Top betting trends & insights to know ahead of Twins at Dodgers

The Dodgers have won 5 of their last 6 home games against the Twins
The Under is 8-2 in the Twins’ last 10 road games
Andy Pages is 8-31 over his last 8 games
Freddie Freeman is 2-12 over his last 4 games
Shohei Ohtani is 4-12 over his last 3 games with 3 HRs

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Twins and the Dodgers

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Twins and the Dodgers:

Moneyline: NBC Sports Bet is recommending a play on the Los Angeles Dodgers on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Los Angeles Dodgers at -1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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