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Orioles at Red Sox Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 23

It’s Friday, May 23 and the Orioles (16-32) are in Boston to take on the Red Sox (25-26). Charlie Morton is slated to take the mound for Baltimore against Lucas Giolito for Boston.

Game 1 of this series was postopined yesterday, which came at a bad time for Baltimore. The Orioles are coming off a 8-4 wn in extra innings that snapped a eight-game losing streak. Morton takes the mound for the O’s and they are 0-12 in his starts this season.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Orioles at Red Sox

Date: Friday, May 23, 2025
Time: 7:10 PM EST
Site: Fenway Park
City: Boston, MA
Network/Streaming: MASN, NESN, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Orioles at the Red Sox

The latest odds as of Friday:

Moneyline: Orioles (+110), Red Sox (-130)
Spread: Red Sox -1.5
Total: 9.0 runs

Probable starting pitchers for Orioles at Red Sox

Pitching matchup for May 23, 2025: Charlie Morton vs. Lucas Giolito
- Orioles: Charlie Morton, (0-7, 7.68 ERA)
  Last outing: 4.1 Innings Pitched, 1 Earned Run Allowed, 2 Hits Allowed, 1 Walk, and 6 Strikeouts
- Red Sox: Lucas Giolito, (1-1, 7.08 ERA)
  Last outing: 4.0 Innings Pitched, 6 Earned Runs Allowed, 8 Hits Allowed, 2 Walks, and 3 Strikeouts

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Expert picks & predictions for tonight’s game between the Orioles and the Red Sox

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Friday’s game between the Orioles and the Red Sox:

Moneyline: NBC Sports Bet is recommending a play on the Boston Red Sox on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles at +1.5.
Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Orioles at Red Sox

The Orioles have lost 4 of their last 5 games
The Over is 8-4 in the Orioles’ matchups against AL East teams this season

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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